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KMID : 0380319900460000151
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Journal of Korean Research Institute for Better Living
1990 Volume.46 No. 0 p.151 ~ p.161
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Dissolution of Promethazine·HCI from the Coprecipitate with Gel forming Excipients
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Abstract
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The coprecipitates of promethazine hydrochloride, a cationic water-soluble as a model drug used drug, with pectin, chondroitin-Na-sulfate and sodium alginate, the gel forming excipients, were studied to determine their dissolution profiles in distilled water and 0.1 N HCI medium by means of the KP dissolution method.
The dissolution rates of the coprecipitate tables were very slow, especially promethazine-alginate coprecipitate tablet in comparison with the intact drug, suggesting that it may be useful for sustained-release preparations.
The formation of the coprecipitates was conformed by powder X-ray diffractometry.
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